EC 1 - Oxidoreductases
EC 1.4 - Acting on the CH-NH2 group of donors
EC 1.4.4 - With a disulfide as acceptor
EC 1.4.4.2 - Glycine dehydrogenase (aminomethyl-transferring)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.4.4.2
Names
Accepted name:
glycine dehydrogenase (aminomethyl-transferring)
Other
names:
P-protein
glycine decarboxylase
glycine-cleavage complex
glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
protein P1
glycine cleavage system P-protein
glycine-cleavage complex P-protein
glycine dehydrogenase (decarboxylating)
glycine decarboxylase
glycine-cleavage complex
glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
protein P1
glycine cleavage system P-protein
glycine-cleavage complex P-protein
glycine dehydrogenase (decarboxylating)
Systematic name:
glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)
Reaction
- glycine + glycine-cleavage complex H protein-N6-lipoyl-L-lysine = glycine-cleavage complex H protein-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2
Cofactor
Comments:
A pyridoxal-phosphate protein. A component of the glycine cleavage system, which is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10, aminomethyltransferase), the L protein (EC 1.8.1.4, dihydrolipoyl dehydrogenase) and the lipoyl-bearing H protein [3]. Previously known as glycine synthase.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0004375
CAS Registry Number:
37259-67-9
GCSP1_ARATH
GCSP1_COLP3
GCSP1_PSEAE
GCSP1_PSEF5
GCSP1_PSEPF
GCSP1_PSEPK
GCSP2_ARATH
GCSP2_COLP3
GCSP2_PSEAE
GCSP2_PSEF5
GCSP2_PSEPF
GCSP2_PSEPK
GCSPA_ACIC5
GCSPA_AERPE
GCSPA_ALCBS
GCSPA_ALKHC
GCSPA_ANAD2
GCSPA_ANADE
GCSPA_ANADF
GCSPA_ANASK
GCSPA_ANOFW
GCSPA_AQUAE
GCSPA_AZOC5
GCSPA_BACAA
GCSPA_BACAC
GCSPA_BACAH
GCSPA_BACAN
GCSPA_BACC0
GCSPA_BACC1
GCSPA_BACC2
GCSPA_BACC3
GCSPA_BACC4
GCSPA_BACC7
GCSPA_BACCN
GCSPA_BACCQ
GCSPA_BACCR
GCSPA_BACCZ
GCSPA_BACHK
GCSPA_BACLD
GCSPA_BACMK
GCSPA_BACP2
GCSPA_BACSK
GCSPA_BACSU
GCSPA_BACVZ
GCSPA_BEII9
GCSPA_BREBN
GCSPA_CALS4
GCSPA_CARHZ
GCSPA_CAUSK
GCSPA_CAUVC
GCSPA_CAUVN
GCSPA_CHLCH
GCSPA_CHLL2
GCSPA_CHLL3
GCSPA_CHLP8
GCSPA_CHLPD
GCSPA_CHLPM
GCSPA_CHLT3
GCSPA_CHLTE
GCSPA_CITBB
GCSPA_COPPD
GCSPA_COXB1
GCSPA_COXB2
GCSPA_COXBN
GCSPA_COXBR
GCSPA_COXBU
GCSPA_DESAG
GCSPA_DESDA
GCSPA_DESHD
GCSPA_DESHY
GCSPA_DESMR
GCSPA_DESPS
GCSPA_DESRM
GCSPA_DESVH
GCSPA_DESVM
GCSPA_DESVV
GCSPA_DICT6
GCSPA_DICTD
GCSPA_ENDTX
GCSPA_ERYLH
GCSPA_EXIS2
GCSPA_FLAPR
GCSPA_FRAP2
GCSPA_FRAT1
GCSPA_FRATF
GCSPA_FRATH
GCSPA_FRATM
GCSPA_FRATN
GCSPA_FRATO
GCSPA_FRATT
GCSPA_FRATW
GCSPA_GEODF
GCSPA_GEOKA
GCSPA_GEOSM
GCSPA_GEOSW
GCSPA_GEOTN
GCSPA_GEOUR
GCSPA_HALHL
GCSPA_HALOH
GCSPA_HALS3
GCSPA_HALSA
GCSPA_HYPNA
GCSPA_KORVE
GCSPA_LEGPA
GCSPA_LEGPC
GCSPA_LEGPH
GCSPA_LEGPL
GCSPA_LISIN
GCSPA_LISMC
GCSPA_LISMF
GCSPA_LISMH
GCSPA_LISMO
GCSPA_LISW6
GCSPA_LYSSC
GCSPA_MACCJ
GCSPA_MAGMM
GCSPA_MAGSA
GCSPA_MARMM
GCSPA_MARSD
GCSPA_METCA
GCSPA_METS5
GCSPA_METSB
GCSPA_MOOTA
GCSPA_NITEC
GCSPA_NITEU
GCSPA_NITMU
GCSPA_NOVAD
GCSPA_OCEIH
GCSPA_PARL1
GCSPA_PARUW
GCSPA_PELPB
GCSPA_PHEZH
GCSPA_PROA2
GCSPA_PYRAB
GCSPA_PYRFU
GCSPA_PYRHO
GCSPA_RHOCS
GCSPA_RHORT
GCSPA_SACS2
GCSPA_SOLUE
GCSPA_SORC5
GCSPA_SPHAL
GCSPA_SPHWW
GCSPA_STAA1
GCSPA_STAA2
GCSPA_STAA3
GCSPA_STAA8
GCSPA_STAA9
GCSPA_STAAC
GCSPA_STAAM
GCSPA_STAAN
GCSPA_STAAR
GCSPA_STAAS
GCSPA_STAAW
GCSPA_STACT
GCSPA_STAEQ
GCSPA_STAES
GCSPA_STAHJ
GCSPA_STAMF
GCSPA_STAS1
GCSPA_SULAC
GCSPA_SULIA
GCSPA_SULIK
GCSPA_SULIL
GCSPA_SULIM
GCSPA_SULIN
GCSPA_SULIY
GCSPA_SULTO
GCSPA_SYNWW
GCSPA_THEAC
GCSPA_THEGJ
GCSPA_THEKO
GCSPA_THEMA
GCSPA_THEON
GCSPA_THEP1
GCSPA_THERP
GCSPA_THESQ
GCSPA_THEVO
GCSPA_THIDA
GCSPA_THISH
GCSPA_XANP2
GCSPB_AERPE
GCSPB_ALKHC
GCSPB_ALKOO
GCSPB_AQUAE
GCSPB_BACAA
GCSPB_BACAC
GCSPB_BACAH
GCSPB_BACAN
GCSPB_BACC0
GCSPB_BACC1
GCSPB_BACC2
GCSPB_BACC3
GCSPB_BACC4
GCSPB_BACC7
GCSPB_BACCN
GCSPB_BACCQ
GCSPB_BACCR
GCSPB_BACCZ
GCSPB_BACHK
GCSPB_BACLD
GCSPB_BACMK
GCSPB_BACSK
GCSPB_BACSU
GCSPB_BACVZ
GCSPB_BREBN
GCSPB_CALS4
GCSPB_CAUVC
GCSPB_CHLCH
GCSPB_CHLL2
GCSPB_CHLPD
GCSPB_CHLPM
GCSPB_CHLT3
GCSPB_CHLTE
GCSPB_COXB1
GCSPB_COXB2
GCSPB_COXBN
GCSPB_COXBR
GCSPB_COXBU
GCSPB_DESRM
GCSPB_ENDTX
GCSPB_EXIS2
GCSPB_FERNB
GCSPB_FLAPR
GCSPB_FRAP2
GCSPB_FRATM
GCSPB_FRATN
GCSPB_FRATW
GCSPB_HALSA
GCSPB_KOSOT
GCSPB_LEGPA
GCSPB_LEGPC
GCSPB_LEGPH
GCSPB_LEGPL
GCSPB_LISIN
GCSPB_LISMC
GCSPB_LISMF
GCSPB_LISMH
GCSPB_LISMO
GCSPB_LISW6
GCSPB_LYSSC
GCSPB_METCA
GCSPB_NITEC
GCSPB_NITEU
GCSPB_NITMU
GCSPB_NITOC
GCSPB_OCEIH
GCSPB_PELPB
GCSPB_PROA2
GCSPB_PSELT
GCSPB_PYRAB
GCSPB_PYRFU
GCSPB_PYRHO
GCSPB_RHOBA
GCSPB_SACS2
GCSPB_STAA1
GCSPB_STAA2
GCSPB_STAA3
GCSPB_STAA8
GCSPB_STAA9
GCSPB_STAAB
GCSPB_STAAC
GCSPB_STAAE
GCSPB_STAAM
GCSPB_STAAN
GCSPB_STAAR
GCSPB_STAAS
GCSPB_STAAT
GCSPB_STAAW
GCSPB_STAEQ
GCSPB_STAES
GCSPB_STAHJ
GCSPB_STAMF
GCSPB_STAS1
GCSPB_SULIA
GCSPB_SULIK
GCSPB_SULIL
GCSPB_SULIM
GCSPB_SULIN
GCSPB_SULIY
GCSPB_SULTO
GCSPB_SYNWW
GCSPB_THEAB
GCSPB_THEAC
GCSPB_THEGJ
GCSPB_THEKO
GCSPB_THEM4
GCSPB_THEMA
GCSPB_THENN
GCSPB_THEON
GCSPB_THEP1
GCSPB_THESQ
GCSPB_THET2
GCSPB_THET8
GCSPB_THEVO
GCSPB_THIDA
GCSPB_THISH
GCSPB_TREDE
GCSP_AGRFC
GCSP_AGRRK
GCSP_AGRVS
GCSP_AKKM8
GCSP_ALIF1
GCSP_ALIFM
GCSP_ALISL
GCSP_AROAE
GCSP_BACFN
GCSP_BACFR
GCSP_BACTN
GCSP_BARHE
GCSP_BARQU
GCSP_BDEBA
GCSP_BORA1
GCSP_BORBR
GCSP_BORPA
GCSP_BORPD
GCSP_BORPE
GCSP_BRADU
GCSP_BRASB
GCSP_BRASO
GCSP_BRUA1
GCSP_BRUA2
GCSP_BRUAB
GCSP_BRUC2
GCSP_BRUMB
GCSP_BRUME
GCSP_BRUO2
GCSP_BRUSI
GCSP_BRUSU
GCSP_BURA4
GCSP_BURCA
GCSP_BURCC
GCSP_BURCH
GCSP_BURCJ
GCSP_BURCM
GCSP_BURL3
GCSP_BURM1
GCSP_BURM7
GCSP_BURM9
GCSP_BURMA
GCSP_BURMS
GCSP_BURP0
GCSP_BURP1
GCSP_BURP6
GCSP_BURPS
GCSP_BURTA
GCSP_BURVG
GCSP_CERS4
GCSP_CERS5
GCSP_CHICK
GCSP_CHRVO
GCSP_CITK8
GCSP_CROS8
GCSP_CUPMC
GCSP_CUPPJ
GCSP_CUTAK
GCSP_DECAR
GCSP_DEIRA
GCSP_DICDI
GCSP_DINSH
GCSP_ECO24
GCSP_ECO27
GCSP_ECO45
GCSP_ECO55
GCSP_ECO57
GCSP_ECO5E
GCSP_ECO7I
GCSP_ECO81
GCSP_ECO8A
GCSP_ECOBW
GCSP_ECODH
GCSP_ECOHS
GCSP_ECOK1
GCSP_ECOL5
GCSP_ECOL6
GCSP_ECOLC
GCSP_ECOLI
GCSP_ECOLU
GCSP_ECOSE
GCSP_ECOSM
GCSP_ECOUT
GCSP_EDWI9
GCSP_ENT38
GCSP_ESCF3
GCSP_FLAAN
GCSP_FLAJ1
GCSP_FLATR
GCSP_GLUOX
GCSP_GRAFK
GCSP_HAHCH
GCSP_HUMAN
GCSP_IDILO
GCSP_JANSC
GCSP_KLEP3
GCSP_KLEP7
GCSP_LEPBJ
GCSP_LEPBL
GCSP_LEPIC
GCSP_LEPIN
GCSP_MOUSE
GCSP_MYCA1
GCSP_MYCBO
GCSP_MYCBP
GCSP_MYCBT
GCSP_MYCGI
GCSP_MYCLB
GCSP_MYCLE
GCSP_MYCPA
GCSP_MYCTA
GCSP_MYCTO
GCSP_MYCTU
GCSP_NEIG1
GCSP_NEIG2
GCSP_NEIM0
GCSP_NEIMA
GCSP_NEIMF
GCSP_NITHX
GCSP_NITWN
GCSP_NOCFA
GCSP_NOSP7
GCSP_NOSS1
GCSP_PARMW
GCSP_PARPJ
GCSP_PARXL
GCSP_PEA
GCSP_PECAS
GCSP_PECCP
GCSP_PELUB
GCSP_PHOLL
GCSP_PHOPR
GCSP_PROM1
GCSP_PROM3
GCSP_PROMA
GCSP_PROMH
GCSP_PROMM
GCSP_PROMT
GCSP_PSE14
GCSP_PSEFS
GCSP_PSESM
GCSP_PSET1
GCSP_PSEU2
GCSP_PSEU5
GCSP_PSYA2
GCSP_PSYCK
GCSP_PSYIN
GCSP_RALPJ
GCSP_RALSO
GCSP_RHIE6
GCSP_RHIEC
GCSP_RHIL3
GCSP_RHILO
GCSP_RHILW
GCSP_RHIME
GCSP_RHOFA
GCSP_RHOP5
GCSP_RHOPA
GCSP_RHOS1
GCSP_RHOSK
GCSP_ROSDO
GCSP_SACD2
GCSP_SALA4
GCSP_SALAR
GCSP_SALDC
GCSP_SALEP
GCSP_SALG2
GCSP_SALHS
GCSP_SALNS
GCSP_SALPB
GCSP_SALPC
GCSP_SALTI
GCSP_SALTY
GCSP_SCHPO
GCSP_SERP5
GCSP_SHEAM
GCSP_SHEB2
GCSP_SHEB5
GCSP_SHEB8
GCSP_SHEB9
GCSP_SHEFN
GCSP_SHEHH
GCSP_SHELP
GCSP_SHEON
GCSP_SHEPA
GCSP_SHEPC
GCSP_SHESA
GCSP_SHESH
GCSP_SHESM
GCSP_SHESR
GCSP_SHESW
GCSP_SHEWM
GCSP_SHIB3
GCSP_SHIBS
GCSP_SHIDS
GCSP_SHIF8
GCSP_SHIFL
GCSP_SHISS
GCSP_SINMW
GCSP_SODGM
GCSP_SOLTU
GCSP_STRAW
GCSP_STRCO
GCSP_STRGG
GCSP_STRM5
GCSP_STRMK
GCSP_SYNR3
GCSP_SYNS9
GCSP_SYNY3
GCSP_TERTT
GCSP_THEVB
GCSP_TRIV2
GCSP_TROW8
GCSP_TROWT
GCSP_VARPS
GCSP_VIBC3
GCSP_VIBCB
GCSP_VIBCM
GCSP_VIBPA
GCSP_VIBVU
GCSP_VIBVY
GCSP_XANAC
GCSP_XANC5
GCSP_XANC8
GCSP_XANCP
GCSP_XANOM
GCSP_XYLFA
GCSP_XYLFT
GCSP_YEAST
GCSP_YERE8
GCSP_YERP3
GCSP_YERPA
GCSP_YERPB
GCSP_YERPE
GCSP_YERPG
GCSP_YERPN
GCSP_YERPP
GCSP_YERPS
GCSP_YERPY
References
-
Hiraga, K. and Kikuchi, G.The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein.J. Biol. Chem. 255 : 11671-11676 (1980). [PMID: 7440563]
-
Perham, R.N.Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.Annu. Rev. Biochem. 69 : 961-1004 (2000). [PMID: 10966480]
-
Nesbitt, N.M., Baleanu-Gogonea, C., Cicchillo, R.M., Goodson, K., Iwig, D.F., Broadwater, J.A., Haas, J.A., Fox, B.G. and Booker, S.J.Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase.Protein Expr. Purif. 39 : 269-282 (2005). [PMID: 15642479]
[EC 1.4.4.2 created 1984, modified 2003, modified 2006, modified 2013]