EC 1.4.4.2 - Glycine dehydrogenase (aminomethyl-transferring)

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IntEnz Enzyme Nomenclature
EC 1.4.4.2

Names

Accepted name:
glycine dehydrogenase (aminomethyl-transferring)
Other names:
P-protein
glycine decarboxylase
glycine-cleavage complex
glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
protein P1
glycine cleavage system P-protein
glycine-cleavage complex P-protein
glycine dehydrogenase (decarboxylating)
Systematic name:
glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)

Reaction

Cofactor

Comments:

A pyridoxal-phosphate protein. A component of the glycine cleavage system, which is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10, aminomethyltransferase), the L protein (EC 1.8.1.4, dihydrolipoyl dehydrogenase) and the lipoyl-bearing H protein [3]. Previously known as glycine synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004375
CAS Registry Number: 37259-67-9
UniProtKB/Swiss-Prot: (537) [show] [UniProt]

References

  1. Hiraga, K. and Kikuchi, G.
    The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein.
    J. Biol. Chem. 255 : 11671-11676 (1980). [PMID: 7440563]
  2. Perham, R.N.
    Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.
    Annu. Rev. Biochem. 69 : 961-1004 (2000). [PMID: 10966480]
  3. Nesbitt, N.M., Baleanu-Gogonea, C., Cicchillo, R.M., Goodson, K., Iwig, D.F., Broadwater, J.A., Haas, J.A., Fox, B.G. and Booker, S.J.
    Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase.
    Protein Expr. Purif. 39 : 269-282 (2005). [PMID: 15642479]

[EC 1.4.4.2 created 1984, modified 2003, modified 2006, modified 2013]