EC 1.4.3.26 - Pre-mycofactocin synthase

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IntEnz Enzyme Nomenclature
EC 1.4.3.26

Names

Accepted name:
pre-mycofactocin synthase
Systematic name:
3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one:oxygen oxidoreductase

Reaction

Comments:

A flavoprotein (FMN). The enzyme participates in the biosynthesis of the enzyme cofactor mycofactocin. The enzyme uses oxygen as an electron source to oxidize a C-N bond, followed by spontaneous exchange with water to form an α-keto moiety on the resulting molecule.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Ayikpoe, R. S., Latham, J. A.
    MftD Catalyzes the Formation of a Biologically Active Redox Center in the Biosynthesis of the Ribosomally Synthesized and Post-translationally Modified Redox Cofactor Mycofactocin.
    J Am Chem Soc 141 : 13582-13591 (2019). [PMID: 31381312]

[EC 1.4.3.26 created 2020]