EC - Protein-lysine 6-oxidase

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IntEnz Enzyme Nomenclature


Accepted name:
protein-lysine 6-oxidase
Other name:
lysyl oxidase
Systematic name:
protein-L-lysine:oxygen 6-oxidoreductase (deaminating)



Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00716
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004720
CAS Registry Number: 99676-44-5
UniProtKB/Swiss-Prot: (24) [show] [UniProt]


  1. Harris, E.D., Gonnerman, W.A., Savage, J.E. and O'Dell, B.L.
    Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta.
    Biochim. Biophys. Acta 341 : 332-344 (1974). [PMID: 4838158]
  2. Rayton, J.K. and Harris, E.D.
    Induction of lysyl oxidase with copper. Properties of an in vitro system.
    J. Biol. Chem. 254 : 621-626 (1979). [PMID: 33171]
  3. Stassen, F.L.H.
    Properties of highly purified lysyl oxidase from embryonic chick cartilage.
    Biochim. Biophys. Acta 438 : 49-60 (1976). [PMID: 7318]
  4. Palamakumbura, A.H. and Trackman, P.C.
    A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples.
    Anal. Biochem. 300 : 245-251 (2002). [PMID: 11779117]
  5. Kagan, H.M., Williams, M.A., Williamson, P.R. and Anderson, J.M.
    Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates.
    J. Biol. Chem. 259 : 11203-11207 (1984). [PMID: 6147351]
  6. Rodriguez, H. M., Vaysberg, M., Mikels, A., McCauley, S., Velayo, A. C., Garcia, C., Smith, V.
    Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor.
    J. Biol. Chem. 285 : 20964-20974 (2010). [PMID: 20439985]
  7. Kim, Y. M., Kim, E. C., Kim, Y.
    The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin.
    Mol. Biol. Rep. 38 : 145-149 (2011). [PMID: 20306300]
  8. Xu, L., Go, E. P., Finney, J., Moon, H., Lantz, M., Rebecchi, K., Desaire, H., Mure, M.
    Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells.
    J. Biol. Chem. 288 : 5357-5363 (2013). [PMID: 23319596]

[EC created 1980, modified 1983]