EC - Lysine 6-dehydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
lysine 6-dehydrogenase
Other names:
L-lysine ε-dehydrogenase
L-lysine 6-dehydrogenase
Systematic name:
L-lysine:NAD+ 6-oxidoreductase (deaminating)



The enzyme is highly specific for L-lysine as substrate, although (S)-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly. While the enzyme from Agrobacterium tumefaciens can use only NAD+, that from the thermophilic bacterium Geobacillus stearothermophilus can also use NADP+, but more slowly [1,4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00068
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050303
CAS Registry Number: 89400-30-6


  1. Misono, H. and Nagasaki, S.
    Occurrence of L-lysine ε-dehydrogenase in Agrobacterium tumefaciens.
    J. Bacteriol. 150: 398-401 (1982). [PMID: 6801024]
  2. Misono, H., Uehigashi, H., Morimoto, E. and Nagasaki, S.
    Purification and properties of L-lysine ε-dehydrogenase from Agrobacterium tumefaciens.
    Agric. Biol. Chem. 49: 2253-2255 (1985).
  3. Misono, H., Hashimoto, H., Uehigashi, H., Nagata, S. and Nagasaki, S.
    Properties of L-lysine ε-dehydrogenase from Agrobacterium tumefaciens.
    J. Biochem. 105: 1002-1008 (1989). [PMID: 2768207]
  4. Heydari, M., Ohshima, T., Nunoura-Kominato, N. and Sakuraba, H.
    Highly stable L-lysine 6-dehydrogenase from the thermophile Geobacillus stearothermophilus isolated from a Japanese hot spring: characterization, gene cloning and sequencing, and expression.
    Appl. Environ. Microbiol. 70: 937-942 (2004). [PMID: 14766574]

[EC created 1989, modified 2006, modified 2011]