EC 1.4.1.12 - 2,4-diaminopentanoate dehydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.4.1.12

Names

Accepted name:
2,4-diaminopentanoate dehydrogenase
Other name:
2,4-diaminopentanoic acid C4 dehydrogenase
Systematic name:
(2R,4S)-2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)

Reactions

Comments:

Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047530
CAS Registry Number: 39346-26-4
UniProtKB/Swiss-Prot:

References

  1. Somack, R. and Costilow, R.N.
    2,4-Diaminopentanoic acid C4 dehydrogenase. Purification and properties of the protein.
    J. Biol. Chem. 248 : 385-388 (1973). [PMID: 4684685]
  2. Stadtman, T.C.
    Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase).
    Adv. Enzymol. Relat. Areas Mol. Biol. 38 : 441-445 (1973).
  3. Tsuda, Y. and Friedmann, H.C.
    Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide.
    J. Biol. Chem. 245 : 5914-5926 (1970). [PMID: 4394942]

[EC 1.4.1.12 created 1976, modified 2017]