EC 1.3.99.8 - 2-furoyl-CoA dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.3.99.8

Names

Accepted name:
2-furoyl-CoA dehydrogenase
Other names:
2-furoyl coenzyme A dehydrogenase
2-furoyl coenzyme A hydroxylase
furoyl-CoA hydroxylase
2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)
Systematic name:
2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)

Reaction

Cofactor

Comments:

A copper protein. The oxygen atom of the -OH produced is derived from water, not O2; the actual oxidative step is probably dehydrogenation of a hydrated form -CHOH-CH2- to -C(OH)=CH-, which tautomerizes non-enzymically to -CO-CH2-, giving (5-oxo-4,5-dihydro-2-furoyl)-CoA. Methylene blue, nitro blue, tetrazolium and a membrane fraction from Pseudomonas putida can act as acceptors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047542
CAS Registry Number: 9068-18-2

References

  1. Kitcher, J.P., Trudgill, P.W. and Rees, J.S.
    Purification and properties of 2-furoyl-coenzyme A hydroxylase from Pseudomonas putida F2.
    Biochem. J. 130: 121-132 (1972).

[EC 1.3.99.8 created 1976]