EC 1.3.99.5 - 3-oxo-5α-steroid 4-dehydrogenase (acceptor)

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IntEnz Enzyme Nomenclature
EC 1.3.99.5

Names

Accepted name:
3-oxo-5α-steroid 4-dehydrogenase (acceptor)
Other names:
3-keto-Δ4-steroid-5α-reductase
3-oxo-5α-steroid Δ4-dehydrogenase
3-oxosteroid Δ4-dehydrogenase
4-ene-3-ketosteroid-5α-oxidoreductase
5α-reductase
Δ4-3-keto steroid 5α-reductase
Δ4-3-ketosteroid5α-oxidoreductase
Δ4-3-oxo steroid reductase
Δ4-3-oxosteroid-5α-reductase
Δ4-5α-dehydrogenase
steroid 5α-reductase
steroid Δ4-5α-reductase
testosterone 5α-reductase
3-oxo-5α-steroid:(acceptor) Δ4-oxidoreductase
tesI (gene name)
Systematic name:
3-oxo-5α-steroid:acceptor Δ4-oxidoreductase

Reaction

Cofactor

Comments:

A flavoprotein. This bacterial enzyme, characterized from Comamonas testosteroni, is involved in androsterone degradation. cf. EC 1.3.1.22, 3-oxo-5α-steroid 4-dehydrogenase (NADP+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003865
CAS Registry Number: 9036-43-5
UniProtKB/Swiss-Prot:

References

  1. Levy, H.R. and Talalay, P.
    Bacterial oxidation of steroids. II. Studies on the enzymatic mechanisms of ring A dehydrogenation.
    J. Biol. Chem. 234 : 2014-2021 (1959). [PMID: 13673006]
  2. Florin, C., Kohler, T., Grandguillot, M., Plesiat, P.
    Comamonas testosteroni 3-ketosteroid-delta 4(5 alpha)-dehydrogenase: gene and protein characterization.
    J. Bacteriol. 178 : 3322-3330 (1996). [PMID: 8655514]
  3. Horinouchi, M., Hayashi, T., Yamamoto, T., Kudo, T.
    A new bacterial steroid degradation gene cluster in Comamonas testosteroni TA441 which consists of aromatic-compound degradation genes for seco-steroids and 3-ketosteroid dehydrogenase genes.
    Appl. Environ. Microbiol. 69 : 4421-4430 (2003). [PMID: 12902225]

[EC 1.3.99.5 created 1965, deleted 2012, modified 2012]