EC 1.3.99.24 - 2-amino-4-deoxychorismate dehydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.3.99.24

Names

Accepted name:
2-amino-4-deoxychorismate dehydrogenase
Other names:
ADIC dehydrogenase
2-amino-2-deoxyisochorismate dehydrogenase
SgcG
Systematic name:
(2S)-2-amino-4-deoxychorismate:FMN oxidoreductase

Reaction

Comments:

The sequential action of EC 2.6.1.86, 2-amino-4-deoxychorismate synthase and this enzyme leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Van Lanen, S.G., Lin, S. and Shen, B.
    Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism.
    Proc. Natl. Acad. Sci. USA 105 : 494-499 (2008). [PMID: 18182490]
  2. Yu, L., Mah, S., Otani, T. and Dedon, P.
    The benzoxazolinate of C-1027 confers intercalative DNA binding.
    J. Am. Chem. Soc. 117 : 8877-8878 (1995).

[EC 1.3.99.24 created 2008]