EC 1.3.99.23 - all-trans-retinol 13,14-reductase

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IntEnz Enzyme Nomenclature
EC 1.3.99.23

Names

Accepted name:
all-trans-retinol 13,14-reductase
Other names:
retinol saturase
RetSat
(13,14)-all-trans-retinol saturase
all-trans-retinol:all-trans-13,14-dihydroretinol saturase
Systematic name:
all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase

Reaction

Comments:

The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0051786
CAS Registry Number: 418767-56-3
UniProtKB/Swiss-Prot:

References

  1. Moise, A.R., Kuksa, V., Imanishi, Y. and Palczewski, K.
    Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase.
    J. Biol. Chem. 279: 50230-50242 (2004). [PMID: 15358783]

[EC 1.3.99.23 created 2005]