EC 1.3.99.18 - Quinaldate 4-oxidoreductase

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IntEnz Enzyme Nomenclature
EC 1.3.99.18

Names

Accepted name:
quinaldate 4-oxidoreductase
Other name:
quinaldic acid 4-oxidoreductase
Systematic name:
quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)

Reaction

Comments:

the enzyme from Pseudomonas sp. AK2 also acts on quinoline-8-carboxylate, whereas that from Serratia marcescens 2CC-1 will oxidize nicotinate; quinaldate is a substrate for both of these enzymes. 2,4,6-Trinitrobenzene sulfonate, 1,4-benzoquinone, 1,2-naphthoquinone, nitroblue tetrazolium, thionine and menadione will serve as an electron acceptor for the former enzyme and ferricyanide for the latter; Meldola blue, iodonitrotetrazolium chloride, phenazine methosulfate, 2,6-dichlorophenolindophenol and cytochrome c will act as electron acceptors for both.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047122
CAS Registry Number: 149885-77-8

References

  1. Sauter, M., Tshisuaka, B., Fetzner, S. and Lingens, F.
    Microbial metabolism of quinoline and related compounds. XX. Quinaldic acid 4-oxidoreductase from Pseudomonas sp. AK-2 compared to other procaryotic molybdenum-containing hydroxylases.
    Biol. Chem. Hoppe Seyler 374: 1037-1046 (1993). [PMID: 8292263]
  2. Fetzner, S. and Lingens, F.
    Microbial metabolism of quinoline and related compounds. XVIII. Purification and some properties of the molybdenum- and iron-containing quinaldic acid 4-oxidoreductase from Serratia marcescens 2CC-1.
    Biol. Chem. Hoppe-Seyler 374: 363-376 (1993). [PMID: 8357532]

[EC 1.3.99.18 created 1999]