EC - Isoquinoline 1-oxidoreductase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
isoquinoline 1-oxidoreductase
Systematic name:
isoquinoline:acceptor 1-oxidoreductase (hydroxylating)



the enzyme from Pseudomonas diminuta is specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline. Electron acceptors include 1,2-benzoquinone, cytochrome c, ferricyanide, iodonitrotetrazolium chloride, nitroblue tetrazolium, Meldola blue and phenazine methosulfate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047121
CAS Registry Number: 155948-73-5


  1. Lehmann, M., Tshisuaka, B., Fetzner, S., Roger, P. and Lingens, F.
    Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase.
    J. Biol. Chem. 269: 11254-11260 (1994). [PMID: 8157655]
  2. Lehmann, M., Tshisuaka, B., Fetzner, S. and Lingens, F.
    Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases.
    J. Biol. Chem. 270: 14420-14429 (1995). [PMID: 7782304]

[EC created 1999]