EC 1.3.8.6 - Glutaryl-CoA dehydrogenase (ETF)

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IntEnz Enzyme Nomenclature
EC 1.3.8.6

Names

Accepted name:
glutaryl-CoA dehydrogenase (ETF)
Other names:
glutaryl coenzyme A dehydrogenase
glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)
glutaryl-CoA dehydrogenase
Systematic name:
glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)

Reaction

Cofactor

Comments:

Contains FAD. The enzyme catalyses the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 4.1.1.70, glutaconyl-CoA decarboxylase). FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyses the oxidation to glutaconyl-CoA (EC 1.3.99.32).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00070
Structural data: CSA , EC2PDB
CAS Registry Number: 37255-38-2
UniProtKB/Swiss-Prot:

References

  1. Besrat, A., Polan, C.E. and Henderson, L.M.
    Mammalian metabolism of glutaric acid.
    J. Biol. Chem. 244: 1461-1467 (1969). [PMID: 4304226]
  2. Hartel, U., Eckel, E., Koch, J., Fuchs, G., Linder, D., Buckel, W.
    Purification of glutaryl-CoA dehydrogenase from Pseudomonas sp., an enzyme involved in the anaerobic degradation of benzoate.
    Arch. Microbiol. 159: 174-181 (1993). [PMID: 8439237]
  3. Dwyer, T. M., Zhang, L., Muller, M., Marrugo, F., Frerman, F.
    The functions of the flavin contact residues, alphaArg249 and betaTyr16, in human electron transfer flavoprotein.
    Biochim. Biophys. Acta 1433: 139-152 (1999). [PMID: 10446367]
  4. Rao, K. S., Albro, M., Dwyer, T. M., Frerman, F. E.
    Kinetic mechanism of glutaryl-CoA dehydrogenase.
    Biochemistry 45: 15853-15861 (2006). [PMID: 17176108]

[EC 1.3.8.6 created 1972 as EC 1.3.99.7, transferred 2012 to EC 1.3.8.6, modified 2013]