EC 1.3.8.3 - (R)-benzylsuccinyl-CoA dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.3.8.3

Names

Accepted name:
(R)-benzylsuccinyl-CoA dehydrogenase
Other names:
BbsG
(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase
Systematic name:
(R)-benzylsuccinyl-CoA:electron transfer flavoprotein oxidoreductase

Reaction

Cofactor

Comments:

Requires FAD as prosthetic group. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity it is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Ferricenium ion is an effective artificial electron acceptor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00070
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Leutwein, C., Heider, J.
    Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and beta-oxidation of the first intermediate, (R)-(+)-benzylsuccinate.
    Microbiology (Reading, Engl.) 145: 3265-3271 (1999). [PMID: 10589736]
  2. Leutwein, C. and Heider, J.
    (R)-Benzylsuccinyl-CoA dehydrogenase of Thauera aromatica, an enzyme of the anaerobic toluene catabolic pathway.
    Arch. Microbiol. 178: 517-524 (2002). [PMID: 12420174]

[EC 1.3.8.3 created 2003 as EC 1.3.99.21, transferred 2012 to EC 1.3.8.3]