IntEnz

EC 1.3.8.15 - 3-(aryl)acrylate reductase

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IntEnz Enzyme Nomenclature
EC 1.3.8.15

Names

Accepted name:

3-(aryl)acrylate reductase

Systematic name:

3-(phenyl)propanoate:electron-transfer flavoprotein 2,3-oxidoreductase

Reactions

59992 [IUBMB]

H⁺

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

oxidized [electron-transfer flavoprotein]

GENERIC:10685

Is ROOT: no
ROOT compound: GENERIC:10684

Number of residues: 1

FAD

Name origin: UniProt - CHECKED (C)

CHEBI:57692

Formula: C27H30N9O15P2
Charge: -3

Position: undefined

ChEBI compound status: CHECKED (C)

phloretate

Name origin: UniProt - CHECKED (C)

CHEBI:16331

Formula: C9H9O3
Charge: -1

ChEBI compound status: CHECKED (C)

(E)-4-coumarate

Name origin: UniProt - CHECKED (C)

CHEBI:12876

Formula: C9H7O3
Charge: -1

ChEBI compound status: CHECKED (C)

reduced [electron-transfer flavoprotein]

GENERIC:10686

Is ROOT: no
ROOT compound: GENERIC:10684

Number of residues: 1

FADH₂

Name origin: UniProt - CHECKED (C)

CHEBI:58307

Formula: C27H33N9O15P2
Charge: -2

Position: undefined

ChEBI compound status: CHECKED (C)

59996 [IUBMB]

3-phenylpropanoate

Name origin: UniProt - CHECKED (C)

CHEBI:51057

Formula: C9H9O2
Charge: -1

ChEBI compound status: CHECKED (C)

H⁺

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

oxidized [electron-transfer flavoprotein]

GENERIC:10685

Is ROOT: no
ROOT compound: GENERIC:10684

Number of residues: 1

FAD

Name origin: UniProt - CHECKED (C)

CHEBI:57692

Formula: C27H30N9O15P2
Charge: -3

Position: undefined

ChEBI compound status: CHECKED (C)

(E)-cinnamate

Name origin: UniProt - CHECKED (C)

CHEBI:15669

Formula: C9H7O2
Charge: -1

ChEBI compound status: CHECKED (C)

reduced [electron-transfer flavoprotein]

GENERIC:10686

Is ROOT: no
ROOT compound: GENERIC:10684

Number of residues: 1

FADH₂

Name origin: UniProt - CHECKED (C)

CHEBI:58307

Formula: C27H33N9O15P2
Charge: -2

Position: undefined

ChEBI compound status: CHECKED (C)

60104 [IUBMB]

3-(1H-indol-3-yl)propanoate

Name origin: UniProt - CHECKED (C)

CHEBI:82916

Formula: C11H10NO2
Charge: -1

ChEBI compound status: CHECKED (C)

H⁺

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

oxidized [electron-transfer flavoprotein]

GENERIC:10685

Is ROOT: no
ROOT compound: GENERIC:10684

Number of residues: 1

FAD

Name origin: UniProt - CHECKED (C)

CHEBI:57692

Formula: C27H30N9O15P2
Charge: -3

Position: undefined

ChEBI compound status: CHECKED (C)

(E)-3-(indol-3-yl)acrylate

Name origin: UniProt - CHECKED (C)

CHEBI:131929

Formula: C11H8NO2
Charge: -1

ChEBI compound status: CHECKED (C)

reduced [electron-transfer flavoprotein]

GENERIC:10686

Is ROOT: no
ROOT compound: GENERIC:10684

Number of residues: 1

FADH₂

Name origin: UniProt - CHECKED (C)

CHEBI:58307

Formula: C27H33N9O15P2
Charge: -2

Position: undefined

ChEBI compound status: CHECKED (C)

Comments:

The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. Unlike EC 1.3.1.31, 2-enoate reductase, this enzyme has minimal activity with crotonate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

References

Dodd, D., Spitzer, M. H., Van Treuren, W., Merrill, B. D., Hryckowian, A. J., Higginbottom, S. K., Le, A., Cowan, T. M., Nolan, G. P., Fischbach, M. A., Sonnenburg, J. L.

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites.

Nature 551 : 648-652 (2017). [PMID: 29168502]

[EC 1.3.8.15 created 2019]

EC 1 - Oxidoreductases

EC 1.3 - Acting on the CH-CH group of donors

EC 1.3.8 - With a flavin as acceptor

EC 1.3.8.15 - 3-(aryl)acrylate reductase

Names

Reactions

Comments:

Links to other databases

References