EC 1.3.8.14 - L-prolyl-[peptidyl-carrier protein] dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.3.8.14

Names

Accepted name:
L-prolyl-[peptidyl-carrier protein] dehydrogenase
Other names:
pigA (gene name)
bmp3 (gene name)
pltE (gene name)
redW (gene name)
Systematic name:
(L-prolyl)-[peptidyl-carrier protein]:electron-transfer flavoprotein oxidoreductase

Reaction

Cofactor

Comments:

Contains FAD. The enzyme participates in the biosynthesis of several pyrrole-containing compounds, such as undecylprodigiosin, prodigiosin, pyoluteorin, and coumermycin A1. It is believed to catalyse the formation of a Δ2-pyrrolin-2-yl(carbonyl)-[peptidyl-carrier protein] intermediate, followed by a two-electron oxidation to 1H-pyrrol-2-carbonyl-[peptidyl-carrier protein].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Thomas, M. G., Burkart, M. D., Walsh, C. T.
    Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis.
    Chem. Biol. 9 : 171-184 (2002). [PMID: 11880032]
  2. Harris, A. K., Williamson, N. R., Slater, H., Cox, A., Abbasi, S., Foulds, I., Simonsen, H. T., Leeper, F. J., Salmond, G. P.
    The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation.
    Microbiology (Reading, Engl.) 150 : 3547-3560 (2004). [PMID: 15528645]

[EC 1.3.8.14 created 2017]