EC - 4-hydroxybenzoyl-CoA reductase

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IntEnz Enzyme Nomenclature


Accepted name:
4-hydroxybenzoyl-CoA reductase
Other names:
4-hydroxybenzoyl-CoA reductase (dehydroxylating)
4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase
Systematic name:
benzoyl-CoA:acceptor oxidoreductase




A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018525


  1. Glockler, R., Tschech, A. and Fuchs, G.
    Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species.
    FEBS Lett. 251: 237-240 (1989). [PMID: 2753161]
  2. Heider, J., Boll, M., Breese, K., Breinig, S., Ebenau-Jehle, C., Feil, U., Gad'on, N., Laempe, D., Leuthner, B., Mohamed, M.E.S., Schneider, S., Burchhardt, G. and Fuchs, G.
    Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica.
    Arch. Microbiol. 170: 120-131 (1998). [PMID: 9683649]
  3. Breese, K. and Fuchs, G.
    4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica - prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins.
    Eur. J. Biochem. 251: 916-923 (1998). [PMID: 9490068]
  4. Brackmann, R. and Fuchs, G.
    Enzymes of anaerobic metabolism of phenolic compounds. 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species.
    Eur. J. Biochem. 213: 563-571 (1993). [PMID: 8477729]
  5. Heider, J. and Fuchs, G.
    Anaerobic metabolism of aromatic compounds.
    Eur. J. Biochem. 243: 577-596 (1997). [PMID: 9057820]

[EC created 2000 as EC, transferred 2011 to EC]