EC - Benzoyl-CoA reductase

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IntEnz Enzyme Nomenclature


Accepted name:
benzoyl-CoA reductase
Other name:
benzoyl-CoA reductase (dearomatizing)
Systematic name:
cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming)




An iron-sulfur protein. Requires Mg2+ or Mn2+. Inactive towards aromatic acids that are not CoA esters but will also catalyse the reaction: ammonia + acceptor + 2 ADP + 2 phosphate = hydroxylamine + reduced acceptor + 2 ATP + H2O. In the presence of reduced acceptor, but in the absence of oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to ADP plus phosphate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018522
CAS Registry Number: 176591-18-7


  1. Boll, M. and Fuchs, G.
    Benzoyl-coenzyme A reductase (dearomatizing), a key enzyme of anaerobic aromatic metabolism. ATP dependence of the reaction, purification and some properties of the enzyme from Thauera aromatica strain K172.
    Eur. J. Biochem. 234: 921-933 (1995). [PMID: 8575453]
  2. Kung, J. W., Baumann, S., von Bergen, M., Muller, M., Hagedoorn, P. L., Hagen, W. R., Boll, M.
    Reversible biological Birch reduction at an extremely low redox potential.
    J. Am. Chem. Soc. 132: 9850-9856 (2010). [PMID: 20578740]

[EC created 1999 as EC, transferred 2011 to EC]