EC - Succinate dehydrogenase (quinone)

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IntEnz Enzyme Nomenclature


Accepted name:
succinate dehydrogenase (quinone)
Other names:
complex II [ambiguous]
succinate dehydrogenase (ubiquinone)
succinate dehydrogenase complex
succinic dehydrogenase
succinate:ubiquinone oxidoreductase
Systematic name:
succinate:quinone oxidoreductase




A flavoprotein (FAD) complex containing iron-sulfur centres. The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. It catalyses succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. cf. EC, fumarate reductase (quinone).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00393
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008177
CAS Registry Number: 9028-11-9
UniProtKB/Swiss-Prot: (76) [show] [UniProt]


  1. Kita, K., Vibat, C. R., Meinhardt, S., Guest, J. R., Gennis, R. B.
    One-step purification from Escherichia coli of complex II (succinate: ubiquinone oxidoreductase) associated with succinate-reducible cytochrome b556.
    J. Biol. Chem. 264 : 2672-2677 (1989). [PMID: 2644269]
  2. Hatefi, Y., Ragan, C.I. and Galante, Y.M.
    The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system.
    In: Martonosi, A. (Ed.) The Enzymes of Biological Membranes , 2nd ed. vol. 4 , Plenum Press , New York , 1985 , 1-70
  3. Figueroa, P., Leon, G., Elorza, A., Holuigue, L., Araya, A., Jordana, X.
    The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana.
    Plant Mol. Biol. 50 : 725-734 (2002). [PMID: 12374303]
  4. Cecchini, G.
    Function and structure of complex II of the respiratory chain.
    Annu. Rev. Biochem. 72 : 77-109 (2003). [PMID: 14527321]
  5. Oyedotun, K. S., Lemire, B. D.
    The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies.
    J. Biol. Chem. 279 : 9424-9431 (2004). [PMID: 14672929]
  6. Kurokawa, T., Sakamoto, J.
    Purification and characterization of succinate:menaquinone oxidoreductase from Corynebacterium glutamicum.
    Arch. Microbiol. 183 : 317-324 (2005). [PMID: 15883782]

[EC created 1983, modified 2014]