EC 1.3.4.1 - Fumarate reductase (CoM/CoB)

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IntEnz Enzyme Nomenclature
EC 1.3.4.1

Names

Accepted name:
fumarate reductase (CoM/CoB)
Other names:
thiol:fumarate reductase
Tfr
Systematic name:
fumarate CoM:CoB oxidoreductase (succinate-forming)

Reaction

Comments:

The enzyme, isolated from the archaeon Methanobacterium thermoautotrophicum, is very oxygen sensitive. It cannot use reduced flavins, reduced coenzyme F420, or NAD(P)H as an electron donor. Distinct from EC 1.3.1.6 [fumarate reductase (NADH)], EC 1.3.5.1 [succinate dehydrogenase (ubiquinone)], and EC 1.3.5.4 [fumarate reductase (quinol)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Khandekar, S. S., Eirich, L. D.
    Purification and characterization of an anabolic fumarate reductase from Methanobacterium thermoautotrophicum.
    Appl. Environ. Microbiol. 55: 856-861 (1989). [PMID: 2499256]
  2. Heim, S., Kunkel, A., Thauer, R. K., Hedderich, R.
    Thiol:fumarate reductase (Tfr) from Methanobacterium thermoautotrophicum--identification of the catalytic sites for fumarate reduction and thiol oxidation.
    Eur. J. Biochem. 253: 292-299 (1998). [PMID: 9578488]

[EC 1.3.4.1 created 2014 as EC 1.3.98.2, transferred 2014 to EC 1.3.4.1]