EC - Protoporphyrinogen oxidase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
protoporphyrinogen oxidase
Other names:
protoporphyrinogen IX oxidase
Systematic name:
protoporphyrinogen-IX:oxygen oxidoreductase




Also slowly oxidizes mesoporphyrinogen IX.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004729
CAS Registry Number: 53986-32-6
UniProtKB/Swiss-Prot: (17) [show] [UniProt]


  1. Poulson, R.
    The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX in mammalian mitochondria.
    J. Biol. Chem. 251 : 3730-3733 (1976). [PMID: 6461]
  2. Poulson, R. and Polglase, W.J.
    The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX. Protoporphyrinogen oxidase activity in mitochondrial extracts of Saccharomyces cerevisiae.
    J. Biol. Chem. 250 : 1269-1274 (1975). [PMID: 234450]
  3. Dailey, H.A. and Dailey, T.A.
    Protoporphyrinogen oxidase of Myxococcus xanthus. Expression, purification, and characterization of the cloned enzyme.
    J. Biol. Chem. 271 : 8714-8718 (1996). [PMID: 8621504]
  4. Wang, K.F., Dailey, T.A. and Dailey, H.A.
    Expression and characterization of the terminal heme synthetic enzymes from the hyperthermophile Aquifex aeolicus.
    FEMS Microbiol. Lett. 202 : 115-119 (2001). [PMID: 11506917]
  5. Corrigall, A.V., Siziba, K.B., Maneli, M.H., Shephard, E.G., Ziman, M., Dailey, T.A., Dailey, H.A., Kirsch. R.E. and Meissner, P.N.
    Purification of and kinetic studies on a cloned protoporphyrinogen oxidase from the aerobic bacterium Bacillus subtilis.
    Arch. Biochem. Biophys. 358 : 251-256 (1998). [PMID: 9784236]
  6. Ferreira, G.C. and Dailey, H.A.
    Mouse protoporphyrinogen oxidase. Kinetic parameters and demonstration of inhibition by bilirubin.
    Biochem. J. 250 : 597-603 (1988). [PMID: 2451512]
  7. Dailey, T.A. and Dailey, H.A.
    Human protoporphyrinogen oxidase: expression, purification, and characterization of the cloned enzyme.
    Protein Sci. 5 : 98-105 (1996). [PMID: 8771201]
  8. Che, F.-S., Watanabe, N., Iwano, M., Inokuchi, H., Takayama, S., Yoshida, S. and Isogai, A.
    Molecular characterization and subcellular localization of protoporphyrinogen oxidase in spinach chloroplasts.
    Plant Physiol. 124 : 59-70 (2000). [PMID: 10982422]
  9. Dailey, T.A. and Dailey, H.A.
    Identification of an FAD superfamily containing protoporphyrinogen oxidases, monoamine oxidases, and phytoene desaturase. Expression and characterization of phytoene desaturase of Myxococcus xanthus.
    J. Biol. Chem. 273 : 13658-13662 (1998). [PMID: 9593705]

[EC created 1978, modified 2003]