EC - Oxazoline dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
oxazoline dehydrogenase
Other names:
azoline oxidase
thiazoline oxidase
cyanobactin oxidase
Systematic name:
a [protein]-2-oxazoline:oxygen oxidoreductase (2-oxazole-forming)



Contains FMN. This enzyme oxidizes 2-oxazoline, 5-methyl-2-oxazoline, and 2-thiazoline within peptides, which were formed by EC, oxazoline synthase, and EC, thiazoline synthase, to the respective pyrrole-type rings. The enzyme is found as either a stand-alone protein or as a domain within a multifunctional protein (the G protein) that also functions as a peptidase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Li, Y. M., Milne, J. C., Madison, L. L., Kolter, R., Walsh, C. T.
    From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase.
    Science 274 : 1188-1193 (1996). [PMID: 8895467]
  2. Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., Ravel, J.
    Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella.
    Proc. Natl. Acad. Sci. U.S.A. 102 : 7315-7320 (2005). [PMID: 15883371]
  3. Bent, A. F., Mann, G., Houssen, W. E., Mykhaylyk, V., Duman, R., Thomas, L., Jaspars, M., Wagner, A., Naismith, J. H.
    Structure of the cyanobactin oxidase ThcOx from Cyanothece sp. PCC 7425, the first structure to be solved at Diamond Light Source beamline I23 by means of S-SAD.
    Acta Crystallogr D Struct Biol 72 : 1174-1180 (2016). [PMID: 27841750]
  4. Ghilarov, D., Stevenson, C. E. M., Travin, D. Y., Piskunova, J., Serebryakova, M., Maxwell, A., Lawson, D. M., Severinov, K.
    Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison.
    Mol. Cell 73 : 749-762.e5 (2019). [PMID: 30661981]

[EC created 2020]