EC - Aclacinomycin-A oxidase

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IntEnz Enzyme Nomenclature


Accepted name:
aclacinomycin-A oxidase
Other names:
AknOx [ambiguous]
aclacinomycin oxidoreductase [ambiguous]
Systematic name:
aclacinomycin-A:oxygen oxidoreductase




A flavoprotein (FAD). This bifunctional enzyme is a secreted flavin-dependent enzyme that is involved in the modification of the terminal sugar residues in the biosynthesis of aclacinomycins. The enzyme utilizes the same active site to catalyse the oxidation of the rhodinose moiety of aclacinomycin N to the cinerulose A moiety of aclacinomycin A (cf. EC and the oxidation of the latter to the L-aculose moiety of aclacinomycin Y.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Yoshimoto, A., Ogasawara, T., Kitamura, I., Oki, T., Inui, T., Takeuchi, T., Umezawa, H.
    Enzymatic conversion of aclacinomycin A to Y by a specific oxidoreductase in Streptomyces.
    J. Antibiot. 32 : 472-481 (1979). [PMID: 528393]
  2. Alexeev, I., Sultana, A., Mantsala, P., Niemi, J., Schneider, G.
    Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.
    Proc. Natl. Acad. Sci. U.S.A. 104 : 6170-6175 (2007). [PMID: 17395717]
  3. Sultana, A., Alexeev, I., Kursula, I., Mantsala, P., Niemi, J., Schneider, G.
    Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning.
    Acta Crystallogr. D Biol. Crystallogr. 63 : 149-159 (2007). [PMID: 17242508]

[EC created 2013]