EC 1.3.3.10 - Tryptophan α,β-oxidase

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IntEnz Enzyme Nomenclature
EC 1.3.3.10

Names

Accepted name:
tryptophan α,β-oxidase
Other names:
L-tryptophan 2',3'-oxidase
L-tryptophan α,β-dehydrogenase
Systematic name:
L-tryptophan:oxygen α,β-oxidoreductase

Reaction

Cofactor

Comments:

Requires heme. The product of the reaction can hydrolyse spontaneously to form indolepyruvate. The enzyme from Chromobacterium violaceum is specific for tryptophan derivatives possessing its carboxyl group free or as an amide or ester, and an unsubstituted indole ring. Also catalyses the α,β dehydrogenation of L-tryptophan side chains in peptides.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050621
CAS Registry Number: 156859-19-7

References

  1. Genet, R., Denoyelle, C. and Menez, A.
    Purification and partial characterization of an amino acid α,β-dehydrogenase, L-tryptophan 2',3'-oxidase from Chromobacterium violaceum.
    J. Biol. Chem. 269: 18177-18184 (1994). [PMID: 8027079]
  2. Genet, R., Benetti, P.H., Hammadi, A. and Menez, A.
    L-Tryptophan 2',3'-oxidase from Chromobacterium violaceum. Substrate specificity and mechanistic implications.
    J. Biol. Chem. 270: 23540-23545 (1995). [PMID: 7559518]

[EC 1.3.3.10 created 2000 as EC 1.4.3.17, transferred 2003 to EC 1.3.3.10]