EC 1.3.1.98 - UDP-N-acetylmuramate dehydrogenase

  IntEnz view ENZYME view
XML

IntEnz Enzyme Nomenclature
EC 1.3.1.98

Names

Accepted name:
UDP-N-acetylmuramate dehydrogenase
Other names:
MurB reductase
UDP-N-acetylenolpyruvoylglucosamine reductase
UDP-N-acetylglucosamine-enoylpyruvate reductase
UDP-GlcNAc-enoylpyruvate reductase
uridine diphospho-N-acetylglucosamine-enolpyruvate reductase
uridine diphosphoacetylpyruvoylglucosamine reductase
uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase
Systematic name:
UDP-N-acetyl-α-D-muramate:NADP+ oxidoreductase

Reaction

Cofactor

Comments:

A flavoprotein (FAD). NADH can to a lesser extent replace NADPH.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008762
CAS Registry Number: 39307-28-3
UniProtKB/Swiss-Prot: (472) [show] [UniProt]

References

  1. Taku, A. and Anwar, R.A.
    Biosynthesis of uridine diphospho-N-acetylmuramic acid. IV. Activation of uridine diphospho-N-acetylenolpyruvylglucosamine reductase by monovalent cations.
    J. Biol. Chem. 248 : 4971-4976 (1973). [PMID: 4717533]
  2. Taku, A., Gunetileke, K.G. and Anwar, R.A.
    Biosynthesis of uridine diphospho-N-acetylmuramic acid. 3. Purification and properties of uridine diphospho-N-acetylenolpyruvyl-glucosamine reductase.
    J. Biol. Chem. 245 : 5012-5016 (1970). [PMID: 4394163]
  3. van Heijenoort, J.
    Recent advances in the formation of the bacterial peptidoglycan monomer unit.
    Nat. Prod. Rep. 18 : 503-519 (2001). [PMID: 11699883]

[EC 1.3.1.98 created 1976 as EC 1.1.1.158, modified 1983, modified 2002, transferred 2013 to EC 1.3.1.98]