EC 1 - Oxidoreductases
EC 1.3 - Acting on the CH-CH group of donors
EC 1.3.1 - With NAD+ or NADP+ as acceptor
EC 1.3.1.94 - Polyprenol reductase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.3.1.94
Names
Accepted name:
polyprenol reductase
Other
names:
SRD5A3 (gene name)
DFG10 (gene name)
DFG10 (gene name)
Systematic name:
ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase
Reaction
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34279 [IUBMB]di-trans,poly-cis-dolicholPOLYMER:9521Formula: C20H36O(C5H8)n
Charge: (0)(0)nNADP+Name origin: UniProt - CHECKED (C)Formula: C21H25N7O17P3
Charge: -3ChEBI compound status: CHECKED (C)=di-trans,cis-polyprenolPOLYMER:9525Formula: C20H34O(C5H8)n
Charge: (0)(0)nH+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)
Comments:
The reaction occurs in the reverse direction with reduction of the terminal double bond next to the alcohol group. Isolated from human fetal brain tissue but present in all eukaryotes. In mammalian cells dolichols are predominantly 18-21 isoprene units in length.
Links to other databases
Gene Ontology:
GO:0102389
References
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Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver.J. Biol. Chem. 268 : 10109-10113 (1993). [PMID: 8486680]
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SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.Cell 142 : 203-217 (2010). [PMID: 20637498]
[EC 1.3.1.94 created 2012]