EC - Polyprenol reductase

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IntEnz Enzyme Nomenclature


Accepted name:
polyprenol reductase
Other names:
SRD5A3 (gene name)
DFG10 (gene name)
Systematic name:
ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase



The reaction occurs in the reverse direction with reduction of the terminal double bond next to the alcohol group. Isolated from human fetal brain tissue but present in all eukaryotes. In mammalian cells dolichols are predominantly 18-21 isoprene units in length.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102389
UniProtKB/Swiss-Prot: (21) [show] [UniProt]


  1. Sagami, H., Kurisaki, A., Ogura, K.
    Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver.
    J. Biol. Chem. 268 : 10109-10113 (1993). [PMID: 8486680]
  2. Cantagrel, V., Lefeber, D. J., Ng, B. G., Guan, Z., Silhavy, J. L., Bielas, S. L., Lehle, L., Hombauer, H., Adamowicz, M., Swiezewska, E., De Brouwer, A. P., Blumel, P., Sykut-Cegielska, J., Houliston, S., Swistun, D., Ali, B. R., Dobyns, W. B., Babovic-Vuksanovic, D., van Bokhoven, H., Wevers, R. A., Raetz, C. R., Freeze, H. H., Morava, E., Al-Gazali, L., Gleeson, J. G.
    SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.
    Cell 142 : 203-217 (2010). [PMID: 20637498]

[EC created 2012]