EC 1.3.1.92 - Artemisinic aldehyde Δ11(13) reductase

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IntEnz Enzyme Nomenclature
EC 1.3.1.92

Names

Accepted name:
artemisinic aldehyde Δ11(13) reductase
Other name:
Dbr2
Systematic name:
artemisinic aldehyde:NADP+ oxidoreductase

Reaction

Comments:

Cloned from Artemisia annua. In addition to the reduction of artemisinic aldehyde it is also able to a lesser extent to reduce artemisinic alcohol and artemisinic acid. Part of the biosyntheis of artemisinin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Bertea, C. M., Freije, J. R., van der Woude, H., Verstappen, F. W., Perk, L., Marquez, V., De Kraker, J. W., Posthumus, M. A., Jansen, B. J., de Groot, A., Franssen, M. C., Bouwmeester, H. J.
    Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua.
    Planta Med. 71 : 40-47 (2005). [PMID: 15678372]
  2. Zhang, Y., Teoh, K. H., Reed, D. W., Maes, L., Goossens, A., Olson, D. J., Ross, A. R., Covello, P. S.
    The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua.
    J. Biol. Chem. 283 : 21501-21508 (2008). [PMID: 18495659]

[EC 1.3.1.92 created 2012]