EC - Crotonyl-CoA carboxylase/reductase

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IntEnz Enzyme Nomenclature


Accepted name:
crotonyl-CoA carboxylase/reductase
Other names:
crotonyl-CoA reductase (carboxylating)
Systematic name:
(2S)-ethylmalonyl-CoA:NADP+ oxidoreductase (decarboxylating)



The reaction is catalysed in the reverse direction. This enzyme, isolated from the bacterium Rhodobacter sphaeroides, catalyses (E)-but-2-enoyl-CoA-dependent oxidation of NADPH in the presence of CO2. When CO2 is absent, the enzyme catalyses the reduction of (E)-but-2-enoyl-CoA to butanoyl-CoA, but with only 10% of maximal activity (relative to (E)-but-2-enoyl-CoA carboxylation).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Erb, T. J., Berg, I. A., Brecht, V., Muller, M., Fuchs, G., Alber, B. E.
    Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway.
    Proc. Natl. Acad. Sci. USA 104: 10631-10636 (2007). [PMID: 17548827]
  2. Erb, T. J., Brecht, V., Fuchs, G., Muller, M., Alber, B. E.
    Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase.
    Proc. Natl. Acad. Sci. USA 106: 8871-8876 (2009). [PMID: 19458256]

[EC created 2010]