EC - Acrylyl-CoA reductase (NADPH)

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IntEnz Enzyme Nomenclature


Accepted name:
acrylyl-CoA reductase (NADPH)
Systematic name:
propanoyl-CoA:NADP+ oxidoreductase




Catalyses a step in the 3-hydroxypropionate/4-hydroxybutyrate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The reaction is catalysed in the opposite direction to that shown. The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA [2]. Different from EC, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16. Contains Zn2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00058
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043957


  1. Berg, I. A., Kockelkorn, D., Buckel, W., Fuchs, G.
    A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
    Science 318: 1782-1786 (2007). [PMID: 18079405]
  2. Teufel, R., Kung, J. W., Kockelkorn, D., Alber, B. E., Fuchs, G.
    3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
    J. Bacteriol. 191: 4572-4581 (2009). [PMID: 19429610]

[EC created 2009]