EC - (+)-pulegone reductase

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IntEnz Enzyme Nomenclature


Accepted name:
(+)-pulegone reductase
Systematic name:
(−)-menthone:NADP+ oxidoreductase



NADH cannot replace NADPH as reductant. The Δ8,9-double bond of (+)-cis-isopulegone and the Δ1,2-double bond of (±)-piperitone are not substrates. The enzyme from peppermint (Mentha x piperita) converts (+)-pulegone into both (−)-menthone and (+)-isomenthone at a ratio of 70:30 for native enzyme but it does not catalyse the reverse reaction. This enzyme is a member of the medium-chain dehydrogenase/reductase superfamily.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052579 , GO:0052580


  1. Ringer, K.L., McConkey, M.E., Davis, E.M., Rushing, G.W. and Croteau, R.
    Monoterpene double-bond reductases of the (−)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (−)-isopiperitenone reductase and (+)-pulegone reductase of peppermint.
    Arch. Biochem. Biophys. 418: 80-92 (2003). [PMID: 13679086]

[EC created 2008]