EC - Arogenate dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature


Accepted name:
arogenate dehydrogenase (NADP+)
Other names:
arogenic dehydrogenase [ambiguous]
pretyrosine dehydrogenase [ambiguous]
Systematic name:
L-arogenate:NADP+ oxidoreductase (decarboxylating)



Arogenate dehydrogenases may utilize NAD+ (EC, NADP+ (EC, or both (EC NADP+-dependent enzymes usually predominate in higher plants. The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033730
CAS Registry Number: 64295-75-6


  1. Gaines, C.G., Byng, G.S., Whitaker, R.J. and Jensen, R.A.
    L-Tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes.
    Planta 156: 233-240 (1982).
  2. Rippert, P. and Matringe, M.
    Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana.
    Eur. J. Biochem. 269: 4753-4761 (2002). [PMID: 12354106]
  3. Bonner, C.A., Jensen, R.A., Gander, J.E. and Keyhani, N.O.
    A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis.
    Biochem. J. 382: 279-291 (2004). [PMID: 15171683]

[EC created 2005]