EC - 2'-hydroxydaidzein reductase

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IntEnz Enzyme Nomenclature


Accepted name:
2'-hydroxydaidzein reductase
Other names:
2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase
NADPH:2'-hydroxydaidzein oxidoreductase
Systematic name:
2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase



In the reverse reaction, the 2'-hydroxyisoflavone (2'-hydroxydaidzein) is reduced to an isoflavanone. Also acts on 2'-hydroxyformononetin and to a small extent on 2'-hydroxygenistein. Involved in the biosynthesis of the phytoalexin glyceollin. The isoflavones biochanin A, daidzein and genestein as well as the flavonoids apigenin, kaempferol and quercetin do not act as substrates.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047525
CAS Registry Number: 126125-01-7


  1. Fischer, D., Ebenau-Jehle, C. and Grisebach, H.
    Phytoalexin synthesis in soybean: purification and characterization of NADPH:2'-hydroxydaidzein oxidoreductase from elicitor-challenged soybean cell cultures.
    Arch. Biochem. Biophys. 276: 390-395 (1990). [PMID: 2306102]

[EC created 1992, modified 2004]