EC - Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)

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IntEnz Enzyme Nomenclature


Accepted name:
enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
Other names:
NADPH 2-enoyl Co A reductase
acyl-ACP dehydrogenase
enoyl-ACp reductase
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase
enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific)
enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific)
acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (A-specific)
acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (Re-specific)
fabL (gene name)
Systematic name:
acyl-[acyl-carrier protein]:NADP+ oxidoreductase (Re-specific)



This enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl-carrier protein. It is one of the activities of EC, animal fatty-acid synthase system. The mammalian enzyme is Re-specific with respect to NADP+ [cf. EC enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and and EC, enoyl-[acyl-carrier-protein] reductase (NADPH)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047117
CAS Registry Number: 37251-09-5 (same number as EC


  1. Dugan, R.E., Slakey, L.L. and Porter, L.W.
    Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate to the acyl chain in the dehydrogenase-catalyzed reactions of fatty acid synthesis.
    J. Biol. Chem. 245: 6312-6316 (1970). [PMID: 4394955]
  2. Carlisle-Moore, L., Gordon, C. R., Machutta, C. A., Miller, W. T., Tonge, P. J.
    Substrate recognition by the human fatty-acid synthase.
    J. Biol. Chem. 280: 42612-42618 (2005). [PMID: 16215233]

[EC created 1986, modified 2013]