EC 1.3.1.39 - Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)

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IntEnz Enzyme Nomenclature
EC 1.3.1.39

Names

Accepted name:
enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
Other names:
NADPH 2-enoyl Co A reductase
acyl-ACP dehydrogenase
enoyl-ACp reductase
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase
enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific)
enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific)
acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (A-specific)
acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (Re-specific)
fabL (gene name)
Systematic name:
acyl-[acyl-carrier protein]:NADP+ oxidoreductase (Re-specific)

Reaction

Comments:

This enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl-carrier protein. It is one of the activities of EC 2.3.1.85, animal fatty-acid synthase. The mammalian enzyme is Re-specific with respect to NADP+ [cf. EC 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and and EC 1.3.1.104, enoyl-[acyl-carrier-protein] reductase (NADPH)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047117
CAS Registry Number: 37251-09-5 (same number as EC 1.3.1.10)
UniProtKB/Swiss-Prot:

References

  1. Dugan, R.E., Slakey, L.L. and Porter, L.W.
    Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate to the acyl chain in the dehydrogenase-catalyzed reactions of fatty acid synthesis.
    J. Biol. Chem. 245: 6312-6316 (1970). [PMID: 4394955]
  2. Carlisle-Moore, L., Gordon, C. R., Machutta, C. A., Miller, W. T., Tonge, P. J.
    Substrate recognition by the human fatty-acid synthase.
    J. Biol. Chem. 280: 42612-42618 (2005). [PMID: 16215233]

[EC 1.3.1.39 created 1986, modified 2013]