EC - Cyclohexane-1-carbonyl-CoA reductase (NADP+)

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IntEnz Enzyme Nomenclature


Accepted name:
cyclohexane-1-carbonyl-CoA reductase (NADP+)
Other names:
1-cyclohexenylcarbonyl-CoA reductase [ambiguous]
chcA (gene name)
Systematic name:
cyclohexane-1-carbonyl-CoA:NADP+ 1-oxidoreductase



The enzyme, characterized from the bacterium Streptomyces collinus, is involved in a pathway that transforms shikimate to cyclohexane-1-carbonyl-CoA by a series of dehydration and double-bond reduction steps. Most of the steps in this process occur with the carboxylic acid activated as a coenzyme A thioester. The enzyme catalyses three steps in this pathway, also acting on (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoyl-CoA and (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Reynolds, K. A., Wang, P., Fox, K. M., Speedie, M. K., Lam, Y., Floss, H. G.
    Purification and characterization of a novel enoyl coenzyme A reductase from Streptomyces collinus.
    J. Bacteriol. 174 : 3850-3854 (1992). [PMID: 1597409]
  2. Wang, P., Denoya, C. D., Morgenstern, M. R., Skinner, D. D., Wallace, K. K., Digate, R., Patton, S., Banavali, N., Schuler, G., Speedie, M. K., Reynolds, K. A.
    Cloning and characterization of the gene encoding 1-cyclohexenylcarbonyl coenzyme A reductase from Streptomyces collinus.
    J. Bacteriol. 178 : 6873-6881 (1996). [PMID: 8955309]

[EC created 2019]