EC 220.127.116.11 - 2-alkenal reductase (NADP+)
IntEnz Enzyme Nomenclature
- an n-alkanal + NADP+ = an alk-2-enal + NADPH + H+
Shows highest activity with 1-nitrocyclohexene but also has significant activity with 2-methylpentenal and trans-cinnamaldehyde . Involved in the detoxication of α,β-unsaturated aldehydes and ketones. Has very low activity with NAD as reductant (cf. EC 18.104.22.168, 2-alkenal reductase [NAD(P)+]).
Links to other databases
A 38 kDa allylic alcohol dehydrogenase from the cultured cells of Nicotiana tabacum.Phytochemistry 55 : 297-303 (2000). [PMID: 11117876]
An enone reductase from Nicotiana tabacum: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant proteins.Bioorg. Chem. 36 : 23-28 (2008). [PMID: 17945329]
Biocatalytic asymmetric alkene reduction: crystal structure and characterization of a double bond reductase from Nicotiana tabacum.ACS Catal. 3 : 370-379 (2013).
[EC 22.214.171.124 created 2013]