EC 1.23.1.4 - (−)-lariciresinol reductase

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IntEnz Enzyme Nomenclature
EC 1.23.1.4

Names

Accepted name:
(−)-lariciresinol reductase
Other names:
pinoresinol/lariciresinol reductase
pinoresinol-lariciresinol reductases
(−)-pinoresinol-(−)-lariciresinol reductase
PLR
Systematic name:
(+)-secoisolariciresinol:NADP+ oxidoreductase

Reaction

Comments:

The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (−)-pinoresinol [EC 1.23.1.3, (−)-pinoresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [1] and Linum corymbulosum [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Fujita, M., Gang, D. R., Davin, L. B., Lewis, N. G.
    Recombinant pinoresinol-lariciresinol reductases from western red cedar (Thuja plicata) catalyze opposite enantiospecific conversions.
    J. Biol. Chem. 274: 618-627 (1999). [PMID: 9872995]
  2. Hemmati, S., Schmidt, T. J., Fuss, E.
    (+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B.
    FEBS Lett. 581: 603-610 (2007). [PMID: 17257599]

[EC 1.23.1.4 created 2013]