EC - (+)-lariciresinol reductase

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IntEnz Enzyme Nomenclature


Accepted name:
(+)-lariciresinol reductase
Other names:
pinoresinol/lariciresinol reductase
pinoresinol-lariciresinol reductases
(+)-pinoresinol-(+)-lariciresinol reductase
Systematic name:
(−)-secoisolariciresinol:NADP+ oxidoreductase



The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (+)-pinoresinol [EC, (+)-pinoresinol reductase]. Isolated from the plants Forsythia intermedia [1,2], Thuja plicata (western red cedar) [3], Linum perenne (perennial flax) [5] and Linum corymbulosum [6].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Chu, A., Dinkova, A., Davin, L. B., Bedgar, D. L., Lewis, N. G.
    Stereospecificity of (+)-pinoresinol and (+)-lariciresinol reductases from Forsythia intermedia.
    J. Biol. Chem. 268 : 27026-27033 (1993). [PMID: 8262939]
  2. Dinkova-Kostova, A. T., Gang, D. R., Davin, L. B., Bedgar, D. L., Chu, A., Lewis, N. G.
    (+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia. Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase.
    J. Biol. Chem. 271 : 29473-29482 (1996). [PMID: 8910615]
  3. Fujita, M., Gang, D. R., Davin, L. B., Lewis, N. G.
    Recombinant pinoresinol-lariciresinol reductases from western red cedar (Thuja plicata) catalyze opposite enantiospecific conversions.
    J. Biol. Chem. 274 : 618-627 (1999). [PMID: 9872995]
  4. Min, T., Kasahara, H., Bedgar, D. L., Youn, B., Lawrence, P. K., Gang, D. R., Halls, S. C., Park, H., Hilsenbeck, J. L., Davin, L. B., Lewis, N. G., Kang, C.
    Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases and their relationship to isoflavone reductases.
    J. Biol. Chem. 278 : 50714-50723 (2003). [PMID: 13129921]
  5. Hemmati, S., Schmidt, T. J., Fuss, E.
    (+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B.
    FEBS Lett. 581 : 603-610 (2007). [PMID: 17257599]
  6. Bayindir, U., Alfermann, A. W., Fuss, E.
    Hinokinin biosynthesis in Linum corymbulosum Reichenb.
    Plant J. 55 : 810-820 (2008). [PMID: 18489708]

[EC created 2013]