EC - Sarcosine reductase

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IntEnz Enzyme Nomenclature


Accepted name:
sarcosine reductase
Systematic name:
acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming)



The reaction is observed only in the direction of sarcosine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for sarcosine binding and methylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC (glycine reductase) and EC (betaine reductase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033794
UniProtKB/Swiss-Prot: (17) [show] [UniProt]


  1. Wagner, M., Sonntag, D., Grimm, R., Pich, A. Eckerskorn, C., Söhling, B. and Andreesen, J.R.
    Substrate-specific selenoprotein B of glycine reductase from Eubacterium acidaminophilum.
    Eur. J. Biochem. 260: 38-49 (1999). [PMID: 10091582]
  2. Hormann, K. and Andreesen, J.R.
    Reductive cleavage of sarcosine and betaine by Eubacterium acidaminophilum via enzyme systems different from glycine reductase.
    Arch. Microbiol. 153: 50-59 (1989).

[EC created 2003]