EC 1 - Oxidoreductases
EC 1.21 - Catalyzing the reaction X-H + Y-H = 'X-Y'
EC 1.21.3 - With oxygen as acceptor
EC 1.21.3.2 - Columbamine oxidase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.21.3.2
Names
Accepted name:
columbamine oxidase
Other
name:
berberine synthase
Systematic name:
columbamine:oxygen oxidoreductase (cyclizing)
Reaction
- 2 columbamine + O2 = 2 berberine + 2 H2O
Cofactor
Comments:
An iron protein. Oxidation of the O-methoxyphenol structure forms the methylenedioxy group of berberine.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ERGO
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0050455
CAS Registry Number:
95329-18-3
References
-
Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis.Tetrahedron Lett. 26 : 201-202 (1985).
[EC 1.21.3.2 created 1989 as EC 1.1.3.26, transferred 2002 to EC 1.21.3.2]