EC - Isopenicillin-N synthase

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IntEnz Enzyme Nomenclature


Accepted name:
isopenicillin-N synthase
Other name:
isopenicillin N synthase
Systematic name:
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)



Forms part of the penicillin biosynthesis pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC51471
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016216
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Huffman, G.W., Gesellchen, P.D., Turner, J.R., Rothenberger, R.B., Osborne, H.E., Miller, F.D., Chapman, J.L. and Queener, S.W.
    Substrate specificity of isopenicillin N synthase.
    J. Med. Chem. 35 : 1897-1914 (1992). [PMID: 1588566]
  2. Roach, P.L., Clifton, I.J., Fulop, V., Harlos, K., Barton, G.J., Hajdu, J., Andersson, I., Schofield, C.J. and Baldwin, J.E.
    Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
    Nature 375 : 700-704 (1995). [PMID: 7791906]

[EC created 2002]