EC 1.20.4.2 - Methylarsonate reductase

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IntEnz Enzyme Nomenclature
EC 1.20.4.2

Names

Accepted name:
methylarsonate reductase
Other names:
MMA(V) reductase
methylarsonate:gluthathione oxidoreductase
Systematic name:
methylarsonate:glutathione oxidoreductase

Reaction

Comments:

The product, methylarsonite, is biologically methylated by EC 2.1.1.137, arsenite methyltransferase, to form cacodylic acid.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050610
UniProtKB/Swiss-Prot: (11) [show] [UniProt]

References

  1. Zakharyan, R.A. and Aposhian, H.V.
    Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase.
    Chem. Res. Toxicol. 12: 1278-1283 (1999). [PMID: 10604879]

[EC 1.20.4.2 created 2000 as EC 1.97.1.7, transfered 2001 to EC 1.20.4.2, modified 2003]