EC 1.2.99.8 - Glyceraldehyde dehydrogenase (FAD-containing)

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IntEnz Enzyme Nomenclature
EC 1.2.99.8

Names

Accepted name:
glyceraldehyde dehydrogenase (FAD-containing)
Other name:
glyceraldehyde oxidoreductase
Systematic name:
D-glyceraldehyde:acceptor oxidoreductase (FAD-containing)

Reaction

Cofactors

Comments:

The enzyme from the archaeon Sulfolobus acidocaldarius catalyses the oxidation of D-glyceraldehyde in the nonphosphorylative Entner-Doudoroff pathway. With 2,6-dichlorophenolindophenol as artificial electron acceptor, the enzyme shows a broad substrate range, but is most active with D-glyceraldehyde. It is not known which acceptor is utilized in vivo. The iron-sulfur protein contains FAD and molybdopterin guanine dinucleotide.

The enzyme from the archaeon Sulfolobus acidocaldarius catalyses the oxidation of D-glyceraldehyde in the nonphosphorylative Entner-Doudoroff pathway. With 2,6-dichlorophenolindophenol as artificial electron acceptor, the enzyme shows a broad substrate range, but is most active with D-glyceraldehyde. It is not known which acceptor is utilized in vivo.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043795
UniProtKB/Swiss-Prot:

References

  1. Kardinahl, S., Schmidt, C. L., Hansen, T., Anemuller, S., Petersen, A., Schafer, G.
    The strict molybdate-dependence of glucose-degradation by the thermoacidophile Sulfolobus acidocaldarius reveals the first crenarchaeotic molybdenum containing enzyme--an aldehyde oxidoreductase.
    Eur. J. Biochem. 260 : 540-548 (1999). [PMID: 10095793]

[EC 1.2.99.8 created 2013]