EC 1.2.99.7 - Aldehyde dehydrogenase (FAD-independent)

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IntEnz Enzyme Nomenclature
EC 1.2.99.7

Names

Accepted name:
aldehyde dehydrogenase (FAD-independent)
Other names:
AORDd
Mop
aldehyde oxidase
aldehyde oxidoreductase
Systematic name:
aldehyde:acceptor oxidoreductase (FAD-independent)

Reaction

Cofactors

Comments:

Belongs to the xanthine oxidase family of enzymes. The enzyme from Desulfovibrio sp. contains a molybdenum-molybdopterin-cytosine dinucleotide (MCD) complex and two types of [2Fe-2S] cluster per monomer, but does not contain FAD.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033727
UniProtKB/Swiss-Prot:

References

  1. Uchida, H., Kondo, D., Yamashita, A., Nagaosa, Y., Sakurai, T., Fujii, Y., Fujishiro, K., Aisaka, K. and Uwajima, T.
    Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690.
    FEMS Microbiol. Lett. 229: 31-36 (2003). [PMID: 14659539]
  2. Duarte, R.O., Archer, M., Dias, J.M., Bursakov, S., Huber, R., Moura, I., Romao, M.J. and Moura, J.J.
    Biochemical/spectroscopic characterization and preliminary X-ray analysis of a new aldehyde oxidoreductase isolated from Desulfovibrio desulfuricans ATCC 27774.
    Biochem. Biophys. Res. Commun. 268: 745-749 (2000). [PMID: 10679276]
  3. Andrade, S.L., Brondino, C.D., Feio, M.J., Moura, I. and Moura, J.J.
    Aldehyde oxidoreductase activity in Desulfovibrio alaskensis NCIMB 13491. EPR assignment of the proximal [2Fe-2S] cluster to the Mo site.
    Eur. J. Biochem. 267: 2054-2061 (2000). [PMID: 10727945]
  4. Romao, M.J., Archer, M., Moura, I., Moura, J.J., LeGall, J., Engh, R., Schneider, M., Hof, P. and Huber, R.
    Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas.
    Science 270: 1170-1176 (1996). [PMID: 7502041]

[EC 1.2.99.7 created 2004]