EC 1.2.98.1 - Formaldehyde dismutase

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IntEnz Enzyme Nomenclature
EC 1.2.98.1

Names

Accepted name:
formaldehyde dismutase
Other names:
aldehyde dismutase
cannizzanase
nicotinoprotein aldehyde dismutase
Systematic name:
formaldehyde:formaldehyde oxidoreductase

Reaction

Cofactors

Comments:

The enzyme contains a tightly but noncovalently bound NADP(H) cofactor, as well as Zn2+ and Mg2+. Enzyme-bound NADPH formed by oxidation of formaldehyde to formate is oxidized back to NADP+ by reaction with a second formaldehyde, yielding methanol. The enzyme from the bacterium Mycobacterium sp. DSM 3803 also catalyses the reactions of EC 1.1.99.36, alcohol dehydrogenase (nicotinoprotein) and EC 1.1.99.37, methanol dehydrogenase (nicotinoprotein) [3]. Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors [1,2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047895
CAS Registry Number: 85204-94-0
UniProtKB/Swiss-Prot:

References

  1. Kato, N., Shirakawa, K., Kobayashi, H. and Sakazawa, C.
    The dismutation of aldehydes by a bacterial enzyme.
    Agric. Biol. Chem. 47 : 39-46 (1983).
  2. Kato, N., Yamagami, T., Shimao, M., Sakazawa, C.
    Formaldehyde dismutase, a novel NAD-binding oxidoreductase from Pseudomonas putida F61.
    Eur. J. Biochem. 156 : 59-64 (1986). [PMID: 3514215]
  3. Park, H., Lee, H., Ro, Y. T., Kim, Y. M.
    Identification and functional characterization of a gene for the methanol : N,N'-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803).
    Microbiology (Reading, Engl.) 156 : 463-471 (2010). [PMID: 19875438]

[EC 1.2.98.1 created 1986 as EC 1.2.99.4, modified 2012, transferred 2015 to EC 1.2.98.1]