EC - Indolepyruvate ferredoxin oxidoreductase

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IntEnz Enzyme Nomenclature


Accepted name:
indolepyruvate ferredoxin oxidoreductase
Other names:
3-(indol-3-yl)pyruvate synthase (ferredoxin)
Systematic name:
3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)




Contains thiamine diphosphate and [4Fe-4S] clusters. Preferentially utilizes the transaminated forms of aromatic amino acids and can use phenylpyruvate and 4-hydroxyphenylpyruvate as substrates. This enzyme, which is found in archaea, is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC, 2-oxoglutarate synthase and EC, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043805
UniProtKB/Swiss-Prot: (12) [show] [UniProt]


  1. Mai, X.H. and Adams, M.W.W.
    Indolepyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus - a new enzyme involved in peptide fermentation.
    J. Biol. Chem. 269: 16726-16732 (1994). [PMID: 8206994]
  2. Siddiqui, M.A., Fujiwara, S. and Imanaka, T.
    Indolepyruvate ferredoxin oxidoreductase from Pyrococcus sp. K0d1 possesses a mosaic: Structure showing features of various oxidoreductases.
    Mol. Gen. Genet. 254: 433-439 (1997). [PMID: 9180697]
  3. Tersteegen, A., Linder, D., Thauer, R.K. and Hedderich, R.
    Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum.
    Eur. J. Biochem. 244: 862-868 (1997). [PMID: 9108258]
  4. Schut, G.J., Menon, A.L. and Adams, M.W.W.
    2-Keto acid oxidoreductases from Pyrococcus furiosus and Thermococcus litoralis.
    Methods Enzymol. 331: 144-158 (2001). [PMID: 11265457]

[EC created 2003]