EC - Aldehyde ferredoxin oxidoreductase

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IntEnz Enzyme Nomenclature


Accepted name:
aldehyde ferredoxin oxidoreductase
Other names:
tungsten-containing aldehyde ferredoxin oxidoreductase
Systematic name:
aldehyde:ferredoxin oxidoreductase




This is an oxygen-sensitive enzyme that contains tungsten-molybdopterin and iron-sulfur clusters. Catalyses the oxidation of aldehydes (including crotonaldehyde, acetaldehyde, formaldehyde and glyceraldehyde) to their corresponding acids. However, it does not oxidize glyceraldehyde 3-phosphate (see EC, glyceralde-3-phosphate ferredoxin reductase). Can use ferredoxin or methylviologen but not NAD(P)+ as electron acceptor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033726
CAS Registry Number: 138066-90-7


  1. Mukund, S. and Adams, M.W.W.
    The novel tungsten-iron-sulfur protein of the hyperthermophilic archaebacterium, Pyrococcus furiosus, is an aldehyde ferredoxin oxidoreductase - evidence for its participation in a unique glycolytic pathway.
    J. Biol. Chem. 266: 14208-14216 (1991). [PMID: 1907273]
  2. Johnson, J.L., Rajagopalan, K.V., Mukund, S. and Adams, M.W.W.
    Identification of molybdopterin as the organic-component of the tungsten cofactor in four enzymes from hyperthermophilic archaea.
    J. Biol. Chem. 268: 4848-4852 (1993). [PMID: 8444863]
  3. Chan, M.K., Mukund, S., Kletzin, A., Adams, M.W.W. and Rees, D.C.
    Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase.
    Science 267: 1463-1469 (1995). [PMID: 7878465]
  4. Roy, R., Menon, A.L. and Adams, M.W.W.
    Aldehyde oxidoreductases from Pyrococcus furiosus.
    Methods Enzymol. 331: 132-144 (2001). [PMID: 11265456]

[EC created 2003]