EC - 2-oxoglutarate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
2-oxoglutarate synthase
Other names:
2-oxoglutarate ferredoxin oxidoreductase
α-ketoglutarate synthase
α-ketoglutarate-ferredoxin oxidoreductase
2-ketoglutarate ferredoxin oxidoreductase
2-oxoglutarate:ferredoxin oxidoreductase
2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)
Systematic name:
2-oxoglutarate:ferredoxin oxidoreductase (decarboxylating)




The enzyme contains thiamine diphosphate and 2 [4Fe-4S] clusters. Highly specific for 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC, pyruvate synthase and EC, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047553
CAS Registry Number: 37251-05-1
UniProtKB/Swiss-Prot: (14) [show] [UniProt]


  1. Buchanan, B.B. and Evans, M.C.W.
    The synthesis of α-ketoglutarate from succinate and carbon dioxide by a subcellular preparation of a photosynthetic bacterium.
    Proc. Natl. Acad. Sci. USA 54: 1212-1218 (1965). [PMID: 4286833]
  2. Gehring, U. and Arnon, D.I.
    Purification and properties of α-ketoglutarate synthase from a photosynthetic bacterium.
    J. Biol. Chem. 247: 6963-6969 (1972). [PMID: 4628267]
  3. Dörner, E. and Boll, M.
    Properties of 2-oxoglutarate:ferredoxin oxidoreductase from Thauera aromatica and its role in enzymatic reduction of the aromatic ring.
    J. Bacteriol. 184: 3975-3983 (2002). [PMID: 12081970]
  4. Mai, X. and Adams, M.W.W.
    Characterization of a fourth type of 2-keto acid-oxidizing enzyme from a hyperthermophilic archaeon: 2-ketoglutarate ferredoxin oxidoreductase from Thermococcus litoralis.
    J. Bacteriol. 178: 5890-5896 (1996). [PMID: 8830683]
  5. Schut, G.J., Menon, A.L. and Adams, M.W.W.
    2-keto acid oxidoreductases from Pyrococcus furiosus and Thermococcus litoralis.
    Methods Enzymol. 331: 144-158 (2001). [PMID: 11265457]

[EC created 1972, modified 2005]