EC - 2-oxoacid oxidoreductase (ferredoxin)

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IntEnz Enzyme Nomenclature


Accepted name:
2-oxoacid oxidoreductase (ferredoxin)
Other name:
Systematic name:
2-oxocarboxylate:ferredoxin 2-oxidoreductase (decarboxylating, CoA-acylating)




Contains thiamine diphosphate and [4Fe-4S] clusters [2]. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For example, see EC, 2-oxoglutarate synthase and EC, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (12) [show] [UniProt]


  1. Kerscher, L., Oesterhelt, D.
    Purification and properties of two 2-oxoacid:ferredoxin oxidoreductases from Halobacterium halobium.
    Eur. J. Biochem. 116 : 587-594 (1981). [PMID: 6266826]
  2. Zhang, Q., Iwasaki, T., Wakagi, T., Oshima, T.
    2-oxoacid:ferredoxin oxidoreductase from the thermoacidophilic archaeon, Sulfolobus sp. strain 7.
    J. Biochem. 120 : 587-599 (1996). [PMID: 8902625]
  3. Fukuda, E., Kino, H., Matsuzawa, H., Wakagi, T.
    Role of a highly conserved YPITP motif in 2-oxoacid:ferredoxin oxidoreductase: heterologous expression of the gene from Sulfolobus sp.strain 7, and characterization of the recombinant and variant enzymes.
    Eur. J. Biochem. 268 : 5639-5646 (2001). [PMID: 11683888]
  4. Fukuda, E., Wakagi, T.
    Substrate recognition by 2-oxoacid:ferredoxin oxidoreductase from Sulfolobus sp. strain 7.
    Biochim. Biophys. Acta 1597 : 74-80 (2002). [PMID: 12009405]
  5. Nishizawa, Y., Yabuki, T., Fukuda, E., Wakagi, T.
    Gene expression and characterization of two 2-oxoacid:ferredoxin oxidoreductases from Aeropyrum pernix K1.
    FEBS Lett. 579 : 2319-2322 (2005). [PMID: 15848165]
  6. Park, Y. J., Yoo, C. B., Choi, S. Y., Lee, H. B.
    Purifications and characterizations of a ferredoxin and its related 2-oxoacid:ferredoxin oxidoreductase from the hyperthermophilic archaeon, Sulfolobus solfataricus P1.
    J. Biochem. Mol. Biol. 39 : 46-54 (2006). [PMID: 16466637]

[EC created 2013]