EC - Pyruvate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
pyruvate synthase
Other names:
pyruvate oxidoreductase
pyruvate synthetase
pyruvate:ferredoxin oxidoreductase
pyruvic-ferredoxin oxidoreductase
2-oxobutyrate synthase
α-ketobutyrate-ferredoxin oxidoreductase
2-ketobutyrate synthase
α-ketobutyrate synthase
2-oxobutyrate-ferredoxin oxidoreductase
2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)
2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propanoylating)
Systematic name:
pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)




Contains thiamine diphosphate and [4Fe-4S] clusters. The enzyme also decarboxylates 2-oxobutyrate with lower efficiency, but shows no activity with 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC, 2-oxoglutarate synthase and EC, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019164
CAS Registry Number: 9082-51-3
UniProtKB/Swiss-Prot: (29) [show] [UniProt]


  1. Evans, M.C.W. and Buchanan, B.B.
    Photoreduction of ferredoxin and its use in carbon dioxide fixation by a subcellular system from a photosynthetic bacterium.
    Proc. Natl. Acad. Sci. USA 53 : 1420-1425 (1965). [PMID: 5217644]
  2. Gehring, U. and Arnon, D.I.
    Purification and properties of α-ketoglutarate synthase from a photosynthetic bacterium.
    J. Biol. Chem. 247 : 6963-6969 (1972). [PMID: 4628267]
  3. Uyeda, K. and Rabinowitz, J.C.
    Pyruvate-ferredoxin oxidoreductase. 3. Purification and properties of the enzyme.
    J. Biol. Chem. 246 : 3111-3119 (1971). [PMID: 5574389]
  4. Uyeda, K. and Rabinowitz, J.C.
    Pyruvate-ferredoxin oxidoreductase. IV. Studies on the reaction mechanism.
    J. Biol. Chem. 246 : 3120-3125 (1971). [PMID: 4324891]
  5. Charon, M.-H., Volbeda, A., Chabriere, E., Pieulle, L. and Fontecilla-Camps, J.C.
    Structure and electron transfer mechanism of pyruvate:ferredoxin oxidoreductase.
    Curr. Opin. Struct. Biol. 9 : 663-669 (1999). [PMID: 10607667]

[EC created 1972, modified 2003, modified 2013]