EC 1.2.4.1 - Pyruvate dehydrogenase (acetyl-transferring)

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IntEnz Enzyme Nomenclature
EC 1.2.4.1

Names

Accepted name:
pyruvate dehydrogenase (acetyl-transferring)
Other names:
PDH
pyruvate decarboxylase [ambiguous]
pyruvate dehydrogenase [ambiguous]
pyruvate dehydrogenase (lipoamide)
pyruvate dehydrogenase complex
pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating)
pyruvic acid dehydrogenase
pyruvic dehydrogenase [ambiguous]
Systematic name:
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)

Reaction

Cofactor

Comments:

Contains thiamine diphosphate. It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex, EC 1.2.1.104, in which it is bound to a core of molecules of EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004739
CAS Registry Number: 9014-20-4
UniProtKB/Swiss-Prot: (123) [show] [UniProt]

References

  1. Ochoa, S.
    Enzymic mechanisms in the citric acid cycle.
    Adv. Enzymol. Relat. Subj. Biochem. 15 : 183-270 (1954).
  2. Scriba, P. and Holzer, H.
    Gewinnung von α-Hydroxyäthyl-2-thiaminpyrophosphat mit Pyruvatoxydase aus Schweineherzmuskel.
    Biochem. Z. 334 : 473-486 (1961).
  3. Perham, R.N.
    Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.
    Annu. Rev. Biochem. 69 : 961-1004 (2000). [PMID: 10966480]

[EC 1.2.4.1 created 1961, modified 2003]