EC - 4-(γ-glutamylamino)butanal dehydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
4-(γ-glutamylamino)butanal dehydrogenase
Other name:
puuC (gene name)
Systematic name:
4-(γ-L-glutamylamino)butanal:NAD(P)+ oxidoreductase



The enzyme, characterized from the bacterium Escherichia coli, is involved in a putrescine catabolic pathway. It has a broad substrate range, and can also catalyse the activities of EC, aminobutyraldehyde dehydrogenase, and EC, succinate-semialdehyde dehydrogenase (NAD+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Kurihara, S., Oda, S., Kato, K., Kim, H. G., Koyanagi, T., Kumagai, H., Suzuki, H.
    A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
    J. Biol. Chem. 280 : 4602-4608 (2005). [PMID: 15590624]
  2. Jo, J. E., Mohan Raj, S., Rathnasingh, C., Selvakumar, E., Jung, W. C., Park, S.
    Cloning, expression, and characterization of an aldehyde dehydrogenase from Escherichia coli K-12 that utilizes 3-Hydroxypropionaldehyde as a substrate.
    Appl. Microbiol. Biotechnol. 81 : 51-60 (2008). [PMID: 18668238]
  3. Schneider, B. L., Reitzer, L.
    Pathway and enzyme redundancy in putrescine catabolism in Escherichia coli.
    J. Bacteriol. 194 : 4080-4088 (2012). [PMID: 22636776]

[EC created 2017]